Modelagem farmacocinética da gentamicina em cães: uma abordagem farmacocinética populacional (popPK)
DOI:
https://doi.org/10.5433/1679-0359.2026v47n1p289Palavras-chave:
Aminoglicosídeos, Canino, Nefrotoxicidade, Farmacometria, Farmacocinética populacional.Resumo
O estudo teve como objetivo avaliar a eficácia e a nefrotoxicidade da gentamicina em cães a partir de um modelo de farmacocinética populacional (popPK). O modelo foi desenvolvido por meio do software Monolix 2024 R1 (Lixoft SAS, Simulations Plus Company), a partir de dados de concentração plasmática extraídos da literatura. Além disso, foram realizadas simulações para doses de 2, 4, 6 e 8 mg kg-1 de gentamicina, no software Simulx 2024 (Lixoft SAS, Simulations Plus Company), avaliando-se o sucesso terapêutico e o risco de toxicidade. O modelo que melhor se ajustou aos dados observados tinha dois compartimentos e eliminação linear. A eficácia terapêutica foi avaliada de acordo com a Probabilidade de Atingir o alvo (PTA) de diferentes concentrações inibitórias mínimas para gentamicina. Para se estimar o risco de toxicidade, foi considerado o tempo acima do limiar tóxico do antibiótico. Assim, com a dose de 8 mg kg-1, foi alcançado um PTA ≥ 90% para bactérias com MIC ≤ 2.0 μg mL-1, e o tempo médio acima da concentração tóxica de gentamicina (0.5 - 2 μg mL-1) variou de 4 a 8 horas. Os resultados sugerem o uso da gentamicina para agentes com MICs ≤ 2 μg mL-1 e intervalo de dose prolongado; no entanto, o profissional deve ajustar a dose e intervalo em pacientes críticos. A abordagem popPK contribui para o aprimoramento da medicina de precisão, garantindo, assim, melhores níveis de eficácia e segurança para diferentes regimes de doses.
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Copyright (c) 2026 Kevellyn Silveira Gomes Martins, Larissa Alexandra Félix, Lucas Wamser Fonseca Gonzaga, Karina Krauss Ferraz Vasconcelos, Diego Díaz, João Vitor Fernandes Cotrim de Almeida, Aline Carvalho Pereira, Marcos Ferrante, Nelsa Widerhon
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