The Geography of Innovation studies how space influences and is influenced by innovative processes, highlighting the importance of spatial agglomeration and the geographic proximity of economic actors. In the context of globalization, cities have undergone intense socio-spatial transformations, resulting in population growth, urban densification, and the consolidation of large urban centers. Smart cities emerge as a response to the challenges of urbanization, using technology to optimize services and urban infrastructure. These cities become innovation laboratories where new methods are tested and urban indicators guide strategic actions. Competition among cities drives improvements in infrastructure and public policies. However, the implementation of smart solutions requires attention to different scales and contexts. In this scenario, the city of Imperatriz (State of Maranhão), a medium-sized city in northeastern Brazil, stands out. This study analyzes how the principles of the Geography of Innovation and smart cities can be applied to the local context, taking into account the urban structural elements. Based on this approach, the study seeks to identify the technological and strategic bottlenecks that hinder Imperatriz’s development, while also recognizing its regional potential and proposing methodological pathways to strengthen the city through innovation and by adapting to local demands.